Since adding Spermidine to my supplement stack, I must say I have been quite pleased with its effect on improving my sleep and hair health. I feel it’s an important supplement to talk about because the benefits were noticeable within 6 weeks of starting it. 

What Is Spermidine?

Spermidine is a polyamine compound that plays a vital role in cell growth, differentiation, and death. It is naturally present in human cells and can also be obtained from certain dietary sources such as wheat germ, soybeans, peas, and mushrooms. However, the levels of spermidine in our bodies decline as we age, which has led scientists to explore its supplementation as a means to potentially slow down the aging process.  

Latest Research on Spermidine:

Numerous studies have shed light on the remarkable effects of spermidine on longevity and overall wellness. In particular, the research conducted by Dr David Sinclair, a renowned Harvard geneticist and longevity expert, has significantly contributed to our understanding of spermidine’s benefits.

Dr. David Sinclair’s Research and Spermidine’s Impact on Longevity:

David Sinclair’s research has demonstrated that spermidine has the potential to increase lifespan in various organisms, including yeast, worms, flies, and mice. In a groundbreaking study published in the journal “Nature Medicine,” Sinclair and his team discovered that supplementing mice with spermidine led to a 10% increase in their average lifespan. This finding has sparked a lot of excitement in the scientific and longevity community and has prompted further exploration of spermidine as a potential anti-aging intervention for humans.

Benefits of Spermidine for Longevity:

According to experts, Spermidine’s potential benefits extend far beyond just cognition and memory enhancement. This compound exhibits neuroprotective properties, shielding neurons from damage induced by inflammation, ischemia, and oxidative stress.

One mechanism through which it accomplishes this is by facilitating the disintegration of amyloid-beta proteins via autophagy. These protein plaques have been found to accumulate in the brain of people with neurodegenerative disorders such as Alzheimer’s. In fact, a study has provided preliminary evidence suggesting that spermidine may mitigate memory loss in elderly individuals afflicted with dementia.

Spermidine acts as a safeguard for DNA, shielding it from damage caused by oxidative stress. It has been observed to stabilize mitochondrial DNA, thereby protecting against aging resulting from mutations in the mitochondrial genome.

Additionally, it has been found that it may guard against telomere attrition in mice, which are the protective caps at the ends of chromosomes that naturally shorten with age, thereby directly influencing lifespan.

Both genomic instability and telomere shortening serve as hallmarks of aging, representing biomarkers used to measure the physiological changes that occur as organisms age. Research indicates that spermidine has the ability to inhibit five out of the nine recognized hallmarks of aging. These are: 

1. Autophagy Stimulation: Spermidine has been shown to stimulate a process called autophagy, which is the body’s natural mechanism for cellular self-cleansing. By enhancing autophagy, spermidine promotes the removal of damaged cellular components, thereby improving cellular health and longevity.
2. Cardiovascular Health: Research suggests that spermidine has positive effects on cardiovascular health. It has been associated with reduced blood pressure, improved heart function, and a lower risk of cardiovascular diseases such as heart failure and hypertension.
3. Cognitive Function: Spermidine has also shown promise in supporting cognitive function and brain health. Studies indicate that it may help protect against age-related cognitive decline and neurodegenerative diseases like Alzheimer’s and Parkinson’s.
4. Anti-Inflammatory Properties: Chronic inflammation is a major contributor to aging and age-related diseases. Spermidine has demonstrated anti-inflammatory effects, which may help reduce the risk of developing chronic conditions associated with aging.

Promoting Wellness with Spermidine:

In addition to its potential effects on longevity, spermidine has been linked to various  other wellness and anti-aging benefits. These include:

1. Improved Sleep Quality: Spermidine has been associated with better sleep quality and increased sleep duration, leading to enhanced overall well-being.
2. Skin Health: Spermidine’s antioxidant properties can protect the skin from oxidative damage, promoting a youthful and healthy complexion.
3. Immune System Support: Spermidine has been found to modulate immune system activity, potentially enhancing immune response and reducing the risk of infections and diseases.

Food Sources of Spermidine: 

• Mushrooms
• Spinach
• Soybeans
• Cauliflower
• Lentils
• Asparagus
• Broccoli
• Egg
• Liver
• Potato
• Beef
• Chickpeas
• Mango

Final Thoughts:

Spermidine, is a remarkable naturally occurring compound that has captured the attention of researchers and health enthusiasts alike due to its potential benefits for longevity and wellness as shown through research studies.

Backed by this groundbreaking research, including the notable work of Dr David Sinclair, spermidine has shown promise in enhancing autophagy, supporting cardiovascular health, improving cognitive function, and exhibiting anti-inflammatory properties. Additionally, spermidine has been linked to improved sleep quality, skin health, and immune system support. 

Preferred Brand of Spermidine: 

Spermidine Supplement by Double Wood. 

About the brand: Double Wood’s Spermidine is over 100x more potent than competing Wheat Germ Extracts that contain only trace amounts of Spermidine.  This Spermidine Supplement by Double Wood has 10mg of 99% Spermidine 3HCL – It’s Third Party Tested.

When choosing a supplement, we always consider several factors such as product quality, brand reputation, customer reviews, and always third-party testing. When buying supplements its important to use only reputable brands that prioritize quality control measures and provide transparent information about the sourcing and manufacturing processes of their products. Additionally, third-party testing can ensure that the supplement meets quality standards and is free from contaminants.

Dosage:

Double Wood recommends starting with a 1-2 capsule dosage of 5-10 mg, which can be increased to a 2-4 capsule dosage of 10 – 20 mg if desired. They don’t recommend exceeding a 4 capsule dosage. This product can be taken with or without food.

As always, consult with your Health Care Practitioner before starting any supplement. 

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